Fentanyl is in a class of medications called narcotic (opiate) analgesics. It works by changing the way the brain and nervous system respond to pain. Fentanyl is 100 times stronger than morphine and 50 times stronger than heroin (DEA, n.d.).
This causes feelings of well-being (euphoria) and relaxation and relieves pain. This campaign also shows the difference between counterfeit pills and real pills. After this point, both the testing and control bands become saturated and the color development rate levels out.
These patches can’t quickly deliver a high dose of fentanyl. From April 2024 to March 2025, the CDC reported 43,000 synthetic opioid deaths, most of which are from fentanyl, down from nearly 70,000 in the previous similar period. Because the drug is less expensive than other opioids, people making it illegally commonly mix it into drugs such as heroin, cocaine, or methamphetamines. If you buy drugs illegally, there is a chance fentanyl can be in them. Fentanyl is a human-made opioid used to treat severe pain. The drug interacts with receptors in your brain to create feelings of pain relief, relaxation, contentment, and pleasure.
NIH-funded Intervention Did Not Impact Opioid-related Overdose Death Rates Over Evaluation Period
One drug, fentanyl, is like rocket fuel in the sharp rise of the crisis. Fentanyl is a painkiller invented in the 1960’s and used to relieve the agony of advanced cancer. But today fentanyl can be ordered on the internet, by drug dealers and addicts, for an online overdose. As we first reported in April, tracking the source of this illicit trade is a story that begins with James Rauh.
Side Effects Of Over-The-Counter Opioids
Read on to learn about the methods, benefits, risks and implications of using or misusing fentanyl. Also, an IV neuromuscular blocker may be employed in cases of severe muscular rigidity to assist the controlled respiration treatments. Fentanyl is hepatically metabolized via the CYP450 enzyme system, specifically CYP3A4. The Centers for Disease Control and Prevention reports that fentanyl is odorless and tasteless, and there is no visible way of knowing if or how much fentanyl a pill contains. But those low-cost test strips can determine whether a drug contains traces of fentanyl.
How To Tell If Someone Has Overdosed On Fentanyl

As a prescription, fentanyl is available under the brand name Actiq, which is a throat lozenge, or Duragesic, a patch placed on the skin. If a person is hospitalized or undergoing surgery, a healthcare professional may administer fentanyl as an injection called Sublimaze. In this article, we will discuss the medical uses of fentanyl and its side effects.

Lifestyle Quizzes

When it is intentionally misused, fentanyl often shows up as a powder, spiked on blotter paper or is mixed with or substituted for heroin and other street drugs. Fentanyl is covered under the Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS) to educate health care providers on treating and monitoring patients with pain. Comparable to fentanyl, fentanyl analogs have similar chemical structure and effects.
Fentanyl, Transdermal Patch
As these are unofficial terms, they can rapidly change and vary from region to region. Healthcare providers, law enforcement, and the public should stay aware of these changes. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Duplication for commercial use must be authorized by ASHP. Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital.
Naloxone: Overdose Reversal Drug

Having “pinpoint pupils” is one symptom of overdose, especially if the pupils do not dilate in response to changes in light. Always have materials (Narcan and the testing strips) and emergency numbers handy. If you suspect someone is having a fentanyl or other opioid overdose, you can administer Narcan to try and revive them. Even if you aren’t 100% sure, Narcan will not hurt the person if they aren’t experiencing an opioid overdose.
- In contrast, someone who has overdosed may fall unconscious rather than asleep.
- A person exhibiting the symptoms of overdose should get immediate medical attention.
- Your doctor will determine the best dosage to suit your needs.
- The side effects of OTC opioids will become stronger with higher doses, at which point the individual can develop slow and shallow breathing and potentially lose consciousness.
- Duplication for commercial use must be authorized by ASHP.
Best Darknet Markets for drugs, counterfeits and digital items. Over 200,000 registered users and over 1,000 worldwide vendors. Fraud-related products, consumer electronicselectronics, self-defense products, and even hosting. Emergent has not announced its price, and it’s not clear yet whether insurers will continue to cover it as a prescription drug if it’s available over the counter. Other brands of naloxone and injectable forms will not yet be available over the counter, but they could be soon. As the person is recovering, you can roll them into the recovery position to prevent any risk of choking on vomit.
So even if you don’t have a firsthand connection to this widespread social problem, you probably know someone who does. Fentanyl transdermal patch is generally used for long-term treatment of severe chronic pain. It comes with serious risks if you don’t take it as prescribed. Being aware if fentanyl is present allows people to implement appropriate harm reduction strategies to reduce the risk of an overdose. Fentanyl is a synthetic opioid that is about 50 times as potent as heroin. People use fentanyl because it is cheap to manufacture and a small amount goes a long way.
Responding To An Overdose
It is typically used to manage severe pain in patients who have built up a tolerance to other opioids. Fentanyl works by binding to the body’s opioid receptors, which are located in the brain and spinal cord, to block pain signals. The fentanyl crisis has become a significant public health issue in recent years. Its potency and widespread availability have contributed to a dramatic increase in opioid-related deaths.
If the person does not respond, you can administer a second dose of Narcan — each package comes with two doses. Naloxone can temporarily restore normal breathing, but the effects only last 30 to 90 minutes. After that time, someone may require another dose, so it’s best that emergency responders are on their way already. Normally, when a person is high on heroin or another opioid, they might go to sleep or slur their words, according to GoodRx. In contrast, someone who has overdosed may fall unconscious rather than asleep.